产品
编 号：F283464
分子式：C14H19NO4
分子量：265.31
分子式：C14H19NO4
分子量：265.31
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
250
In-stock
10mg
400
In-stock
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 22862-76-6
产品详情
生物活性：
Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. Anisomycin is a JNK activator, which increases phospho-JNK. Anisomycin is a bacterial antibiotic.
体内研究：
Anisomycin (60 mg/kg; for 4-week continuous intravenous administration) significantly decreases mouse body weight in a dose-related manner, compared with the control group. Anisomycin (15 mg/kg; for 4-week continuous intravenous administration) slightly and transiently decreases the mouse body weight. There is no significant difference of the mouse body weight in 5 mg/kg group.Animal Model:Balb/c mice of both sexes (4-5 weeks old)
Dosage:84, 99, 116, 136 or 160 mg/kg; 0.2 mL per mouse
Administration:Intravenously injected through mouse tail vein
Result:The calculated LD50 for Anisomycin was 119.64 mg/kg.
体外研究：
To examine whether JNK has a core role in colistin-induced neurotoxicity in PC-12 cells, an SP600125 (a highly selective inhibitor of JNK) and Anisomycin (a potent activator) are used in this study. In order to select an appropriate concentration, PC-12 cells are treated with a range of SP600125 (0-80 μM) and Anisomycin (0-20 μM) respectively for 24 h. The results show that the cells viability significantly decreases by SP600125 treatment in a concentration-dependent manner, observed at the concentrations greater than 20 μM (pAnisomycin 相关抗体:
Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. Anisomycin is a JNK activator, which increases phospho-JNK. Anisomycin is a bacterial antibiotic.
体内研究：
Anisomycin (60 mg/kg; for 4-week continuous intravenous administration) significantly decreases mouse body weight in a dose-related manner, compared with the control group. Anisomycin (15 mg/kg; for 4-week continuous intravenous administration) slightly and transiently decreases the mouse body weight. There is no significant difference of the mouse body weight in 5 mg/kg group.Animal Model:Balb/c mice of both sexes (4-5 weeks old)
Dosage:84, 99, 116, 136 or 160 mg/kg; 0.2 mL per mouse
Administration:Intravenously injected through mouse tail vein
Result:The calculated LD50 for Anisomycin was 119.64 mg/kg.
体外研究：
To examine whether JNK has a core role in colistin-induced neurotoxicity in PC-12 cells, an SP600125 (a highly selective inhibitor of JNK) and Anisomycin (a potent activator) are used in this study. In order to select an appropriate concentration, PC-12 cells are treated with a range of SP600125 (0-80 μM) and Anisomycin (0-20 μM) respectively for 24 h. The results show that the cells viability significantly decreases by SP600125 treatment in a concentration-dependent manner, observed at the concentrations greater than 20 μM (pAnisomycin 相关抗体:
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备