产品
编 号:F283198
分子式:C16H12ClN3O
分子量:297.74
产品类型
结构图
CAS No: 2280037-51-4
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产品详情
生物活性:
Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription.
体外研究:
Bobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells.