产品
编 号：F282966
分子式：C14H17Cl2F3N6O
分子量：413.23
分子式：C14H17Cl2F3N6O
分子量：413.23
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CAS No: 227449-73-2
产品详情
生物活性：
Syk Inhibitor II dihydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride shows less potent against other kinases and has anti-allergic effect.
体内研究：
Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride 在抗原攻击前 30 分钟皮下给药，以剂量依赖方式抑制过敏反应，ID50 值为13.2 mg/kg。Animal Model:ICR mice
Dosage:10, 30, 100 mg/kg
Administration:S.c.; 30 min before antigen challenge
Result:Inhibited the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg.
体外研究：
Syk Inhibitor II (compound 9a) dihydrochloride 对 PKCε、PKCβ2、ZAP-70、Btk 和 Itk 的作用较弱，IC50 值分别为 5.1 μM、11 μM、11.2 μM、15.5 μM 和 22.6 μM。
Syk Inhibitor II dihydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride shows less potent against other kinases and has anti-allergic effect.
体内研究：
Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride 在抗原攻击前 30 分钟皮下给药，以剂量依赖方式抑制过敏反应，ID50 值为13.2 mg/kg。Animal Model:ICR mice
Dosage:10, 30, 100 mg/kg
Administration:S.c.; 30 min before antigen challenge
Result:Inhibited the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg.
体外研究：
Syk Inhibitor II (compound 9a) dihydrochloride 对 PKCε、PKCβ2、ZAP-70、Btk 和 Itk 的作用较弱，IC50 值分别为 5.1 μM、11 μM、11.2 μM、15.5 μM 和 22.6 μM。
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