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编 号：F282262
分子式：C26H56N10
分子量：508.79
分子式：C26H56N10
分子量：508.79
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CAS No: 22573-93-9
产品详情
生物活性：
Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis.
体内研究：
Alexidine (Jugular vein-catheterized; 48 hours; 3?μg/ml; once) can decimate preformed biofilms growing in the jugular vein catheters of mice.Animal Model:8-week-old C57BL/6 male mice
Dosage:3?μg/ml
Administration:Jugular vein-catheterized, 48 hours, 3?μg/ml, once
Result:Inhibited 67% of fungal biofilm growth and viability, compared to the control untreated biofilms.
体外研究：
Alexidine (10?μM, 24 hours) treatment can decimate the biofilm community.Alexidine (0-60 μg/ml, 24 hours) treatment can kill HUVECs and lung A549 cells.
Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis.
体内研究：
Alexidine (Jugular vein-catheterized; 48 hours; 3?μg/ml; once) can decimate preformed biofilms growing in the jugular vein catheters of mice.Animal Model:8-week-old C57BL/6 male mice
Dosage:3?μg/ml
Administration:Jugular vein-catheterized, 48 hours, 3?μg/ml, once
Result:Inhibited 67% of fungal biofilm growth and viability, compared to the control untreated biofilms.
体外研究：
Alexidine (10?μM, 24 hours) treatment can decimate the biofilm community.Alexidine (0-60 μg/ml, 24 hours) treatment can kill HUVECs and lung A549 cells.
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