产品
编 号：F281554
分子式：C21H20Cl2N2O6S
分子量：499.36
分子式：C21H20Cl2N2O6S
分子量：499.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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结构图
CAS No: 2244452-09-1
产品详情
生物活性：
BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h.
体外研究：
BI-4924 是一种高效的辅因子烟酰胺腺嘌呤二核苷酸 (NADH/NAD+) 竞争性 PHGDH 抑制剂。BI-4924 对大多数其他脱氢酶靶标显示出高选择性。
BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h.
体外研究：
BI-4924 是一种高效的辅因子烟酰胺腺嘌呤二核苷酸 (NADH/NAD+) 竞争性 PHGDH 抑制剂。BI-4924 对大多数其他脱氢酶靶标显示出高选择性。
产品资料
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