产品
编 号：F280225
分子式：C18H20N8O2
分子量：380.4
分子式：C18H20N8O2
分子量：380.4
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 2230820-11-6
产品详情
生物活性：
AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity.
体内研究：
AZD-7648 (100 mg/kg; p.o.; once daily for 5 days) induces tumour growth inhibition and tumour regression.Animal Model:Nude mice, A549 xenografts and NCI-H1299 xenografts
Dosage:100 mg/kg
Administration:Oral administration, once daily for 5 days
Result:Induced tumour growth inhibition in combination with IR in A549 xenografts and induced tumour regression in combination with IR in NCI-H1299 xenografts.
体外研究：
AZD7648 (0-30 μM) is a potent radiosensitizer.AZD7648 (3 μM) increases sensitivity to doxorubicin.AZD7648 (0.6 μM) enhances the activity of PARP inhibitor olaparib.
AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity.
体内研究：
AZD-7648 (100 mg/kg; p.o.; once daily for 5 days) induces tumour growth inhibition and tumour regression.Animal Model:Nude mice, A549 xenografts and NCI-H1299 xenografts
Dosage:100 mg/kg
Administration:Oral administration, once daily for 5 days
Result:Induced tumour growth inhibition in combination with IR in A549 xenografts and induced tumour regression in combination with IR in NCI-H1299 xenografts.
体外研究：
AZD7648 (0-30 μM) is a potent radiosensitizer.AZD7648 (3 μM) increases sensitivity to doxorubicin.AZD7648 (0.6 μM) enhances the activity of PARP inhibitor olaparib.
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