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编 号：F280172
分子式：C25H40N2O4
分子量：432.6
分子式：C25H40N2O4
分子量：432.6
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CAS No: 222989-99-3
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生物活性：
Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia.
体内研究：
Finasteride (0.1-0.5 mg/kg; p.o. once daily for 16 weeks) reduces prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration.Animal Model:Male dogs with spontaneous BPH (2.7-11 years old; 10.3-49 kg)
Dosage:0.1-0.5 mg/kg
Administration:P.o. once daily for 16 weeks
Result:Decreased prostatic diameter (20%), prostatic volume (43%), and serum DHT concentration (58%).Decreased semen volume but did not adversely effect on semen quality or serum testosterone concentration.No adverse effects on dogs.
体外研究：
Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells.Finasteride decreases the conversion of [3H]testosterone (T) to [3H]dihydrotestosterone (DHT)in P. crustosum.
Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia.
体内研究：
Finasteride (0.1-0.5 mg/kg; p.o. once daily for 16 weeks) reduces prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration.Animal Model:Male dogs with spontaneous BPH (2.7-11 years old; 10.3-49 kg)
Dosage:0.1-0.5 mg/kg
Administration:P.o. once daily for 16 weeks
Result:Decreased prostatic diameter (20%), prostatic volume (43%), and serum DHT concentration (58%).Decreased semen volume but did not adversely effect on semen quality or serum testosterone concentration.No adverse effects on dogs.
体外研究：
Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells.Finasteride decreases the conversion of [3H]testosterone (T) to [3H]dihydrotestosterone (DHT)in P. crustosum.
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