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编 号:F279837
分子式:C25H26N6O2
分子量:442.51
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生物活性:
FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases. FM-381 is a potent covalent reversible inhibitor of?JAK3?targeting the unique Cys909. FM-381 has an?IC50?of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

体外研究:
FM-479 is the inactive control of FM-381, the concentration used in assays is similar.
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