产品
编 号：F279705
分子式：C20H30BrNO3
分子量：412.36
分子式：C20H30BrNO3
分子量：412.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
25mg
询价
询价
50mg
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询价
100mg
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询价
结构图
CAS No: 22254-24-6
产品详情
生物活性：
Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with IC50s of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide relaxes smooth muscle, can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma.
体内研究：
Ipratropium bromide (1.0 μg/kg；静脉注射；单剂量) 增强迷走神经刺激引起的支气管收缩。Ipratropium bromide (0.04 mg/20 mL 和 0.20 mg/20 mL；30 min，rate=30 mL/30 min) 可以通过减少中性粒细胞的实质炎症浸润来保护肺免受镉诱导的急性中性粒细胞炎症。Animal Model:Guinea-pigs of the Dunkin Hartley strain.
Dosage:0.1-1 μg/kg
Administration:Intravenous injection; single dose
Result:Resulted little blocking effect on post-junctional muscarinic receptors at 0.3 μg/kg, and inhibited ACh-induced bronchoconstriction at 0.5 μg/kg.
Animal Model:Male Sprague-Dawley rats (300-350 g)
Dosage:0.04 mg/20 mL and 0.20 mg/20 mL
Administration:Inhalation; atomization rate of 30 mL/30 min; 30 min
Result:Had no significant effects on any parameters recorded in healthy rats but exerted a protective effect against the inflammatory reaction elicited by cadmium.
体外研究：
Ipratropium bromide (1 nM、10 nM、100 nM；15 分钟) 通过破坏线粒体膜电位发挥其毒性作用。Ipratropium bromide (1 nM-1 μM；4 h) 在离体灌注心脏缺血/再灌注实验中以剂量反应方式增加梗塞面积 (EC50=22.7 nM)。Ipratropium bromide (0.001 nM-0.1 mM；2 h) 在缺氧处理 4 小时后抑制成年大鼠心肌细胞生长。
Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with IC50s of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide relaxes smooth muscle, can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma.
体内研究：
Ipratropium bromide (1.0 μg/kg；静脉注射；单剂量) 增强迷走神经刺激引起的支气管收缩。Ipratropium bromide (0.04 mg/20 mL 和 0.20 mg/20 mL；30 min，rate=30 mL/30 min) 可以通过减少中性粒细胞的实质炎症浸润来保护肺免受镉诱导的急性中性粒细胞炎症。Animal Model:Guinea-pigs of the Dunkin Hartley strain.
Dosage:0.1-1 μg/kg
Administration:Intravenous injection; single dose
Result:Resulted little blocking effect on post-junctional muscarinic receptors at 0.3 μg/kg, and inhibited ACh-induced bronchoconstriction at 0.5 μg/kg.
Animal Model:Male Sprague-Dawley rats (300-350 g)
Dosage:0.04 mg/20 mL and 0.20 mg/20 mL
Administration:Inhalation; atomization rate of 30 mL/30 min; 30 min
Result:Had no significant effects on any parameters recorded in healthy rats but exerted a protective effect against the inflammatory reaction elicited by cadmium.
体外研究：
Ipratropium bromide (1 nM、10 nM、100 nM；15 分钟) 通过破坏线粒体膜电位发挥其毒性作用。Ipratropium bromide (1 nM-1 μM；4 h) 在离体灌注心脏缺血/再灌注实验中以剂量反应方式增加梗塞面积 (EC50=22.7 nM)。Ipratropium bromide (0.001 nM-0.1 mM；2 h) 在缺氧处理 4 小时后抑制成年大鼠心肌细胞生长。
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