产品
编 号：F279388
分子式：C7H10N2O2S
分子量：186.23
分子式：C7H10N2O2S
分子量：186.23
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
询价
询价
1g
询价
询价
结构图
CAS No: 22232-54-8
产品详情
生物活性：
Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research.
体内研究：
Carbimazole (10, 15, 20 mg/每只/每日, 口服, 21 d) 对家兔基本生理参数表现出总体上剂量依赖性的影响。Animal Model:local breed adult healthy male rabbits
Dosage:10, 15, 20 mg/animal/day
Administration:Oral gavage (p.o.) for 21 d
Result:Decreased rectal temperature, respiration rate, heart rate, the packed cell volume, Hb concentration and total leukocyte count, significantly decreased plasma glucose level; Increased serum levels of total protein, globulins while serum albumin level decreased; Lowered serum urea level while there was an increase in serum urea level with increase in dose level; Increased serum cholesterol level in a dose-dependent manner.
体外研究：
Carbimazole (0.01-2 mM, 6 h) 抑制 SK-N-SH 细胞中蛋白质的整体翻译水平。Carbimazole (0.5 mM, 12-72 h) 在无氧环境下通过抑制蛋白合成和激活 MAPK 抑制缺氧 SK-N-SH 的细胞损伤，并维持细胞内 ATP 含量。
Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research.
体内研究：
Carbimazole (10, 15, 20 mg/每只/每日, 口服, 21 d) 对家兔基本生理参数表现出总体上剂量依赖性的影响。Animal Model:local breed adult healthy male rabbits
Dosage:10, 15, 20 mg/animal/day
Administration:Oral gavage (p.o.) for 21 d
Result:Decreased rectal temperature, respiration rate, heart rate, the packed cell volume, Hb concentration and total leukocyte count, significantly decreased plasma glucose level; Increased serum levels of total protein, globulins while serum albumin level decreased; Lowered serum urea level while there was an increase in serum urea level with increase in dose level; Increased serum cholesterol level in a dose-dependent manner.
体外研究：
Carbimazole (0.01-2 mM, 6 h) 抑制 SK-N-SH 细胞中蛋白质的整体翻译水平。Carbimazole (0.5 mM, 12-72 h) 在无氧环境下通过抑制蛋白合成和激活 MAPK 抑制缺氧 SK-N-SH 的细胞损伤，并维持细胞内 ATP 含量。
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