产品
编 号：F031204
分子式：C5H8O4
分子量：132.11
分子式：C5H8O4
分子量：132.11
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
400
In-stock
结构图
CAS No: 108-59-8
产品详情
生物活性：
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis.
体内研究：
Dimethyl malonate (6 mg/kg/min；静脉输注；51 分钟) 促进大鼠心脏骤停后的自主循环 (ROSC) 恢复和神经功能。Animal Model:Sprague-Dawley male rats, cardiac arrest model
Dosage:6 mg/kg/min
Administration:Intravenous infusion, 51 min
Result:Improved ROSC after CA. Prevented the decline in neurological function and inhibited the apoptosis of hippocampal neurons at day 3 after CPR. Inhibited caspase-3 cleavage and increased HIF-1α expression at day 3 after CPR. Decreased the level of oxidative stress at day 3 after CPR. Inhibited excessive hyperpolarization of MMP and restrained the leakage of cytochrome C after 45 min reperfusion.
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis.
体内研究：
Dimethyl malonate (6 mg/kg/min；静脉输注；51 分钟) 促进大鼠心脏骤停后的自主循环 (ROSC) 恢复和神经功能。Animal Model:Sprague-Dawley male rats, cardiac arrest model
Dosage:6 mg/kg/min
Administration:Intravenous infusion, 51 min
Result:Improved ROSC after CA. Prevented the decline in neurological function and inhibited the apoptosis of hippocampal neurons at day 3 after CPR. Inhibited caspase-3 cleavage and increased HIF-1α expression at day 3 after CPR. Decreased the level of oxidative stress at day 3 after CPR. Inhibited excessive hyperpolarization of MMP and restrained the leakage of cytochrome C after 45 min reperfusion.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备