产品
编 号：F277200
分子式：C27H25N3O4S2
分子量：519.64
分子式：C27H25N3O4S2
分子量：519.64
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 219832-49-2
产品详情
生物活性：
MP-A08 is a highly selective ATP competitive sphingosine kinase (SPHK1) inhibitor that targets both SphK1 and SphK2 with Ki values of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.
体内研究：
MP-A08 suppresses the growth of human lung tumor xenografts in mice.
体外研究：
MP-A08 blocks pro-proliferative signalling pathways, induces mitochondrial-associated apoptosis in a SK-dependent manner, and reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis. MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type.
MP-A08 is a highly selective ATP competitive sphingosine kinase (SPHK1) inhibitor that targets both SphK1 and SphK2 with Ki values of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.
体内研究：
MP-A08 suppresses the growth of human lung tumor xenografts in mice.
体外研究：
MP-A08 blocks pro-proliferative signalling pathways, induces mitochondrial-associated apoptosis in a SK-dependent manner, and reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis. MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type.
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