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编 号：F277147
分子式：C26H26FN5O
分子量：443.52
分子式：C26H26FN5O
分子量：443.52
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CAS No: 219769-23-0
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SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC50=1.7 μM), p38α (Kd=0.47 nM), BRDT (1) (IC50=18 μM) and BRD4 (1)(IC50=3.7 μM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET).
SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC50=1.7 μM), p38α (Kd=0.47 nM), BRDT (1) (IC50=18 μM) and BRD4 (1)(IC50=3.7 μM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET).
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