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编 号：F277037
分子式：C19H20FN5O4
分子量：401.39
分子式：C19H20FN5O4
分子量：401.39
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CAS No: 219680-11-2
产品详情
生物活性：
Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including?Steptococcus aureus,?Streptococcus pyogenes?and?S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP).
体外研究：
Zabofloxacin shows a highly potent in vitro activity against clinical isolates of penicillin-sensitive?S. pneumoniae?(minimum inhibitory concentration, MIC90: 0.03 mg/L) and penicillin-resistant?S. pneumoniae?(MIC90: 0.03 mg/L). Against quinolone-resistant?S. pneumoniae,?zabofloxacin (MIC90: 1 mg/L) is more active than ciprofloxacin, sparfloxacin, and moxifloxacin.
Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including?Steptococcus aureus,?Streptococcus pyogenes?and?S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP).
体外研究：
Zabofloxacin shows a highly potent in vitro activity against clinical isolates of penicillin-sensitive?S. pneumoniae?(minimum inhibitory concentration, MIC90: 0.03 mg/L) and penicillin-resistant?S. pneumoniae?(MIC90: 0.03 mg/L). Against quinolone-resistant?S. pneumoniae,?zabofloxacin (MIC90: 1 mg/L) is more active than ciprofloxacin, sparfloxacin, and moxifloxacin.
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