产品
编 号：F276978
分子式：C15H10O4
分子量：254.24
分子式：C15H10O4
分子量：254.24
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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50mg
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结构图
CAS No: 2196-14-7
产品详情
生物活性：
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 μM.
体内研究：
7,4'-Dihydroxyflavone (6?μg，口服灌胃，4 周) 抑制小鼠哮喘模型中支气管肺泡灌洗 (BAL) 液中 MUC5AC 的分泌。
体外研究：
7,4'-Dihydroxyflavone (10 μM，72-120 小时) 抑制 HFL-1 细胞中组成型嗜酸细胞趋化因子的产生。7,4'-Dihydroxyflavone (10 μM，72 小时) 可降低 HFL-1 细胞中 IL-4/TNF-α 刺激的 p-STAT6、p-IκBα 和 p-Akt 表达。7,4'-Dihydroxyflavone (10 μM，30 分钟) 抑制 Phorbol 12-myristate 13-acetate (HY-18739) (10 ng/mL，持续 24 小时) 诱导的 NCI-H292 细胞中 MUC5AC 的产生和基因表达。
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 μM.
体内研究：
7,4'-Dihydroxyflavone (6?μg，口服灌胃，4 周) 抑制小鼠哮喘模型中支气管肺泡灌洗 (BAL) 液中 MUC5AC 的分泌。
体外研究：
7,4'-Dihydroxyflavone (10 μM，72-120 小时) 抑制 HFL-1 细胞中组成型嗜酸细胞趋化因子的产生。7,4'-Dihydroxyflavone (10 μM，72 小时) 可降低 HFL-1 细胞中 IL-4/TNF-α 刺激的 p-STAT6、p-IκBα 和 p-Akt 表达。7,4'-Dihydroxyflavone (10 μM，30 分钟) 抑制 Phorbol 12-myristate 13-acetate (HY-18739) (10 ng/mL，持续 24 小时) 诱导的 NCI-H292 细胞中 MUC5AC 的产生和基因表达。
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