产品
编 号：F276508
分子式：C16H18ClNO4
分子量：323.77
分子式：C16H18ClNO4
分子量：323.77
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
25mg
400
In-stock
50mg
640
In-stock
100mg
960
In-stock
结构图
CAS No: 2188-68-3
产品详情
生物活性：
Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM).
体内研究：
Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.Animal Model:6- to 8-week-old BALB/C nude mice
Dosage:0 μg, 7.5 μg, 15 μg
Administration:Subcutaneous injection; for 14 days
Result:Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
体外研究：
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected.Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.
Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM).
体内研究：
Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.Animal Model:6- to 8-week-old BALB/C nude mice
Dosage:0 μg, 7.5 μg, 15 μg
Administration:Subcutaneous injection; for 14 days
Result:Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
体外研究：
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected.Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.
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