产品
编 号：F276477
分子式：C12H17N3O2S
分子量：267.35
分子式：C12H17N3O2S
分子量：267.35
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 218795-74-5
产品详情
生物活性：
IMM-01 is a mammalian Diaphanous (mDia)-related formins agonist that inhibits DID-DAD (diaphanous inhibitory domain-diaphanous autoregulatory domain) binding with an IC50 of 140 nM. IMM-01 acts by disrupting the autoinhibitory bond between the DID and DAD domain and thus activates formins. IMM-01 shows anticancer effects.
体内研究：
IMM-01（5-25 mg/kg；静脉注射；每周 2 次；持续 3 周）能够减缓结肠癌小鼠异种移植模型中的肿瘤生长。Animal Model:Athymic nude female mice (6 to 8 weeks) implanted with SW480 cells
Dosage:5 mg/kg, 25 mg/kg
Administration:i.v.; 2 times a week; for 3 weeks
Result:Slowed tumor growth in a dose-dependent manner when administered intravenously via the tail vein.
体外研究：
IMM-01（100 μM；1 小时）可诱导 SW480 结肠癌细胞中的微管稳定。IMM-01 (10 μM) 显着诱导 NIH 3T3-SRE-LacZ 细胞中 LacZ 的表达。IMM-01（1-100 μM；48 小时）在 NIH 3T3 细胞和 SW480 细胞凋亡诱导过程中诱导 caspase-3 裂解。
IMM-01 is a mammalian Diaphanous (mDia)-related formins agonist that inhibits DID-DAD (diaphanous inhibitory domain-diaphanous autoregulatory domain) binding with an IC50 of 140 nM. IMM-01 acts by disrupting the autoinhibitory bond between the DID and DAD domain and thus activates formins. IMM-01 shows anticancer effects.
体内研究：
IMM-01（5-25 mg/kg；静脉注射；每周 2 次；持续 3 周）能够减缓结肠癌小鼠异种移植模型中的肿瘤生长。Animal Model:Athymic nude female mice (6 to 8 weeks) implanted with SW480 cells
Dosage:5 mg/kg, 25 mg/kg
Administration:i.v.; 2 times a week; for 3 weeks
Result:Slowed tumor growth in a dose-dependent manner when administered intravenously via the tail vein.
体外研究：
IMM-01（100 μM；1 小时）可诱导 SW480 结肠癌细胞中的微管稳定。IMM-01 (10 μM) 显着诱导 NIH 3T3-SRE-LacZ 细胞中 LacZ 的表达。IMM-01（1-100 μM；48 小时）在 NIH 3T3 细胞和 SW480 细胞凋亡诱导过程中诱导 caspase-3 裂解。
产品资料
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