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编 号:F275807
分子式:C41H79N3O12
分子量:806.08
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
Tulathromycin A (Tulathromycin), a macrolide antibiotic, inhibits protein synthesis (IC50=0.26 μM) by targeting bacterial ribosome. Tulathromycin A is used for the research of respiratory disease in cattle and swine. Immunomodulatory effects.

体内研究:
In the lungs of both A pleuropneumoniae- and zymosan-challenged pigs, Tulathromycin A (2.5 mg/kg, IM) promotes leukocyte apoptosis and efferocytosis and inhibites proinflammatory leukotriene B4 production, with a concurrent reduction in leukocyte necrosis relative to that of control pigs. Tulathromycin A also attenuates the degree of lung damage and lesion progression in A pleuropneumoniae-inoculated pigs.

体外研究:
Tulathromycin A (Tulathromycin) represents the first member of a novel subclass of macrolides, known as triamilides.Tulathromycin A (0.02 to 2.0 mg/mL) induces time- and concentration-dependent apoptosis in neutrophils, which enhances their subsequent clearance by macrophages.
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