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编 号:F275480
分子式:C34H42MgN6O9S2
分子量:767.17
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生物活性:
Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent and orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium trihydrate has the potential for upper intestinal disorders and gastroesophageal reflux disease research. Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases.

体内研究:
Esomeprazole magnesium (0.5-50 mg/kg; oral gavage; daily; for 10 days; A/J mice) treatment increases gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity.Animal Model:A/J mice
Dosage:0.5 mg/kg, 5 mg/kg, 50 mg/kg
Administration:Oral gavage; daily; for 10 days
Result:Gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity are increased.

体外研究:
Esomeprazole magnesium trihydrate is develped from Esomeprazole strontium tetrahydrate (EST). EST contains esomeprazole, the S-enantiomer of omeprazole a salt-exchanged version of Esomeprazole magnesium trihydrate.
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