产品
编 号:F275421
分子式:C19H19N5OS
分子量:365.45
产品类型
结构图
CAS No: 2170136-65-7
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产品详情
生物活性:
GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity.
体外研究:
GSK-3484862 (0-10 μM, 6 or 14 days) induces dramatic DNA methylation loss.?GSK-3484862 (0-10 μM, 4 days) results in a modest reduction in DNMT1 protein level.