产品
编 号：F273876
分子式：C31H37N5O3
分子量：527.66
分子式：C31H37N5O3
分子量：527.66
产品类型
规格
价格
是否有货
结构图
CAS No: 215529-47-8
产品详情
生物活性：
Bamirastine inhibits ligand binding to recombinant human histamine H1 receptors (rhH1R) with an IC50 value of 17.3 nM.
体内研究：
Bamirastine (TAK-427) inhibits histamine induced skin reactions in guinea pigs and mice with an ID50 value of 0.884 and 0.450 mg/kg, p.o., respectively; significant inhibition associated with 10 mg/kg of Bamirastine is still observed 24 h after dosing in guinea pigs. Even at 300 mg/kg, Bamirastine does not affect pentobarbital-induced sleeping time in mice. Bamirastine significantly inhibits passive cutaneous anaphylaxis (PCA) in mice and guinea pigs, and also inhibits antigen-induced ISRs in guinea pigs.
体外研究：
Bamirastine (TAK-427) reduces specific binding of [3H] pyrilamine to recombinant human H1 receptors (rhH1R) is seen in a concentration- dependent manner with an IC50 value of 17.3 nM. The Ki value is calculated to be 7.35 nM. The affinity of Bamirastine is found to be as high as that of azelastine, 2 times lower than that of Epinastine, 8 times lower than that of ketotifen and 3 times higher than that of Terfenadine.
Bamirastine inhibits ligand binding to recombinant human histamine H1 receptors (rhH1R) with an IC50 value of 17.3 nM.
体内研究：
Bamirastine (TAK-427) inhibits histamine induced skin reactions in guinea pigs and mice with an ID50 value of 0.884 and 0.450 mg/kg, p.o., respectively; significant inhibition associated with 10 mg/kg of Bamirastine is still observed 24 h after dosing in guinea pigs. Even at 300 mg/kg, Bamirastine does not affect pentobarbital-induced sleeping time in mice. Bamirastine significantly inhibits passive cutaneous anaphylaxis (PCA) in mice and guinea pigs, and also inhibits antigen-induced ISRs in guinea pigs.
体外研究：
Bamirastine (TAK-427) reduces specific binding of [3H] pyrilamine to recombinant human H1 receptors (rhH1R) is seen in a concentration- dependent manner with an IC50 value of 17.3 nM. The Ki value is calculated to be 7.35 nM. The affinity of Bamirastine is found to be as high as that of azelastine, 2 times lower than that of Epinastine, 8 times lower than that of ketotifen and 3 times higher than that of Terfenadine.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备