产品
编 号：F273713
分子式：C29H31N7O3
分子量：525.6
分子式：C29H31N7O3
分子量：525.6
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规格
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是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 2152628-33-4
产品详情
生物活性：
Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity.
体内研究：
Selpercatinib (LOXO-292; 10 mg/kg; i.g.; for 0-2 h) has good pharmacokinetics after oral gavage in FVB/NRj mice.Pharmacokinetic Parameters of Selpercatinib in FVB/NRj mice.Administrationi.g. (10 mg/kg)
Tmax (h)1.8
Cmax (ng/mL)7862
AUC (ng·h/mL)26649
FVB/NRj mice, 10 mg/kg i.g.Animal Model:Male FVB/NRj mice
Dosage:10 mg/kg
Administration:Oral gavage; for 7.5 min, 15 min, 30 min, 1 h and 2 h (Pharmacokinetic Analysis)
Result:Had good pharmacokinetics after oral gavage in FVB/NRj mice.
Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity.
体内研究：
Selpercatinib (LOXO-292; 10 mg/kg; i.g.; for 0-2 h) has good pharmacokinetics after oral gavage in FVB/NRj mice.Pharmacokinetic Parameters of Selpercatinib in FVB/NRj mice.Administrationi.g. (10 mg/kg)
Tmax (h)1.8
Cmax (ng/mL)7862
AUC (ng·h/mL)26649
FVB/NRj mice, 10 mg/kg i.g.Animal Model:Male FVB/NRj mice
Dosage:10 mg/kg
Administration:Oral gavage; for 7.5 min, 15 min, 30 min, 1 h and 2 h (Pharmacokinetic Analysis)
Result:Had good pharmacokinetics after oral gavage in FVB/NRj mice.
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