产品
编 号：F272691
分子式：C15H9Cl2FN4
分子量：335.16
分子式：C15H9Cl2FN4
分子量：335.16
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
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询价
结构图
CAS No: 2138882-71-8
产品详情
生物活性：
KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity.
体内研究：
KEA1-97 (5 mg/kg; i.p.; 50 days) attenuates tumor xenograft growth.Animal Model:Immune-deficient SCID mice
Dosage:5 mg/kg
Administration:I.p.; 50 days
Result:Attenuated tumor xenograft growth.
体外研究：
KEA1-97 (100 μM; 231MFP cells) impaires thioredoxin pulldown of caspase 3.KEA1-97 (10 μM; 48 hours; 231MFP cells) impaires 231MFP serum-free cell proliferation.KEA1-97 (10 μM; 0~12 hours; 231MFP cells) activates caspase 3/7 and induces apoptotic cell death.KEA1-97 (231MFP cells) resistants to survival and proliferation impairments.
KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity.
体内研究：
KEA1-97 (5 mg/kg; i.p.; 50 days) attenuates tumor xenograft growth.Animal Model:Immune-deficient SCID mice
Dosage:5 mg/kg
Administration:I.p.; 50 days
Result:Attenuated tumor xenograft growth.
体外研究：
KEA1-97 (100 μM; 231MFP cells) impaires thioredoxin pulldown of caspase 3.KEA1-97 (10 μM; 48 hours; 231MFP cells) impaires 231MFP serum-free cell proliferation.KEA1-97 (10 μM; 0~12 hours; 231MFP cells) activates caspase 3/7 and induces apoptotic cell death.KEA1-97 (231MFP cells) resistants to survival and proliferation impairments.
产品资料
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