产品
编 号：F272315
分子式：C13H12O4S
分子量：264.3
分子式：C13H12O4S
分子量：264.3
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2133499-85-9
产品详情
生物活性：
HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition.
体外研究：
HSP27 inhibitor J2 (10 μM；12 h) 在 NCI-H460 中诱导显著异常的 HSP27 二聚体形成。 HSP27 inhibitor J2 (10 μM；24 h) 增加 17-AAG-诱导 shCTRL 细胞凋亡。
HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition.
体外研究：
HSP27 inhibitor J2 (10 μM；12 h) 在 NCI-H460 中诱导显著异常的 HSP27 二聚体形成。 HSP27 inhibitor J2 (10 μM；24 h) 增加 17-AAG-诱导 shCTRL 细胞凋亡。
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