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编 号:F030220
分子式:C26H30Cl4N4O2
分子量:572.35
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生物活性:
HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity.

体外研究:
HM03 trihydrochloride (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 μM concentration in HCT116 cells.HM03 trihydrochloride forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins.HM03 trihydrochloride exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays.
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