产品
编 号:F270758
分子式:C32H44Br2N4O4
分子量:708.52
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
W-84 (dibromide) is a potent allosteric modulator of M2-cholinoceptors, which retards [3H]N-methylscopolamine dissociation. W-84 dibromide can stabilize cholinergic antagonist-receptor complexes. W-84 (dibromide) is a non-competitive muscarinic acetylcholine receptors antagonist with allosteric effects. W-84 (dibromide) protects over additively against an organophosphate-intoxication when applied in combination with atropine.

体外研究:
The stabilizing effect of W-84 (dibromide) on antagonist-receptor complexes may explain the overadditive protective action exerted by the combination of atropine and W-84 (dibromide) against organophosphate intoxication. W-84 (dibromide) not only inhibits radioligand association but also strongly stabilizes antagonist-receptor complexes.
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