产品
编 号：F270243
分子式：C19H24FN5O7S
分子量：485.49
分子式：C19H24FN5O7S
分子量：485.49
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
询价
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50mg
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100mg
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结构图
CAS No: 210353-53-0
产品详情
生物活性：
Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections.
体内研究：
Gemifloxacin has favorable pharmacokinetic profile in animals after oral administration.Pharmacokinetic Parameters of Gemifloxacin in Sprague-Dawley rats and dogs.SpeciesAdministrationAUC0-24 (μg/mL·h) Half-life (h) Cmax (μg/mL) Tmax (h) F (%)
Ratp.o.; 20 mg/kg8.502.332.440.3395.3
Dogp.o.; 4 mg/kg7.555.121.341.1371
体外研究：
Gemifloxacin has higher antibacterial activity than Moxifloxacin (HY-66011A) against Streptococcus pneumoniae with a MIC90 of 0.06 μg/mL.Gemifloxacin has highly potent antibacterial activity against Penicillin-resistant strains of S. pneumoniae with a MIC90 of 0.03 μg/mL.
Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections.
体内研究：
Gemifloxacin has favorable pharmacokinetic profile in animals after oral administration.Pharmacokinetic Parameters of Gemifloxacin in Sprague-Dawley rats and dogs.SpeciesAdministrationAUC0-24 (μg/mL·h) Half-life (h) Cmax (μg/mL) Tmax (h) F (%)
Ratp.o.; 20 mg/kg8.502.332.440.3395.3
Dogp.o.; 4 mg/kg7.555.121.341.1371
体外研究：
Gemifloxacin has higher antibacterial activity than Moxifloxacin (HY-66011A) against Streptococcus pneumoniae with a MIC90 of 0.06 μg/mL.Gemifloxacin has highly potent antibacterial activity against Penicillin-resistant strains of S. pneumoniae with a MIC90 of 0.03 μg/mL.
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