产品
编 号:F270042
分子式:C38H27F2N7O6S
分子量:747.73
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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生物活性:
JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM.

体内研究:
The possibility that mutations within the JAK2 JH2 domain may be associated with pathology, which is associated with a hyperactive kinase and a hematopoietic malignancy phenotype in flies.?Specific mutation in the JAK2 JH2 domain is associated with several myeloproliferative diseases.

体外研究:
JAK2 JH2 Tracer shows a minimum tracer concentration that retains a satisfactory signal-to-noise ratio is found to be 1.5 pM.?JAK2 JH2 Tracer shows a dissociation constants near 0.2 μM.?JAK2 JH2 Tracer shows a high binding affinity with a Kd value of 0.2 μM for JAK2 JH2 domain by saturation experiments.
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