产品
编 号：F270029
分子式：C29H30O13
分子量：586.54
分子式：C29H30O13
分子量：586.54
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 21018-84-8
产品详情
生物活性：
Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK.
体内研究：
Amarogentin (100 mg/kg，口服) 可缓解四氯化碳 (HY-Y0298) 诱导的肝纤维化，降低小鼠中 α-SMA 和 TGF-β1 的表达。Animal Model:Carbon tetrachloride (HY-Y0298)-induced liver fibrosis mice model
Dosage:100 mg/kg
Administration:p.o.
Result:Decreased hepatic α-SMA and TGF-β1 expression.Inhibited phosphorylation of JNK, ERK, and p38.
体外研究：
Amarogentin (0-20 μM，24 小时) 通过抑制氧化应激来显示对酵母的抗衰老作用。Amarogentin (0-10 μM，24 小时) 抑制 PC12 细胞中 H2O2 诱导的氧化损伤 (降低细胞内 ROS 水平和 MDA 含量)。
Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK.
体内研究：
Amarogentin (100 mg/kg，口服) 可缓解四氯化碳 (HY-Y0298) 诱导的肝纤维化，降低小鼠中 α-SMA 和 TGF-β1 的表达。Animal Model:Carbon tetrachloride (HY-Y0298)-induced liver fibrosis mice model
Dosage:100 mg/kg
Administration:p.o.
Result:Decreased hepatic α-SMA and TGF-β1 expression.Inhibited phosphorylation of JNK, ERK, and p38.
体外研究：
Amarogentin (0-20 μM，24 小时) 通过抑制氧化应激来显示对酵母的抗衰老作用。Amarogentin (0-10 μM，24 小时) 抑制 PC12 细胞中 H2O2 诱导的氧化损伤 (降低细胞内 ROS 水平和 MDA 含量)。
产品资料
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