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编 号:F259493
分子式:C20H23N9O
分子量:405.46
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1mg
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生物活性:
CHK1-IN-3 is a Checkpoint Kinase 1 (CHK1) inhibitor with an IC50 of 0.4 nM.

体内研究:
CHK1-IN-3 significantly suppresses the tumor growth in Z-138 cell inoculated xenograft model as a single agent with body weight unaffected.

体外研究:
CHK1-IN-3 effectively inhibites the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 μM) and displays low affinity for hERG (IC50 > 40 μM).
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