产品
编 号：F259303
分子式：C25H20F3N5O2
分子量：479.45
分子式：C25H20F3N5O2
分子量：479.45
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2095849-04-8
产品详情
生物活性：
CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM.
体内研究：
CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept..Animal Model:Male CD-1 mice, 25-35 grams (8-11 weeks old)
Dosage:2 mg/kg IV or 10 mg/kg orally (Per Os)
Administration:i.v. or oral
Result:I.V.: Cmax=3.55, T1/2=0.87P.O.: Cmax=4.6, T1/2=1.8, Bioavailability=64%
体外研究：
CSF1R is thought to play an important role in recruitment and differentiation of tumor-associated macrophages (TAMs). CSF1R-IN-1 (compound 22) shows good intestinal permeability in a Caco2 assay.
CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM.
体内研究：
CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept..Animal Model:Male CD-1 mice, 25-35 grams (8-11 weeks old)
Dosage:2 mg/kg IV or 10 mg/kg orally (Per Os)
Administration:i.v. or oral
Result:I.V.: Cmax=3.55, T1/2=0.87P.O.: Cmax=4.6, T1/2=1.8, Bioavailability=64%
体外研究：
CSF1R is thought to play an important role in recruitment and differentiation of tumor-associated macrophages (TAMs). CSF1R-IN-1 (compound 22) shows good intestinal permeability in a Caco2 assay.
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