产品
编 号：F259158
分子式：C25H27F3N2O4
分子量：476.49
分子式：C25H27F3N2O4
分子量：476.49
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
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5mg
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10mg
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结构图
CAS No: 2095128-17-7
产品详情
生物活性：
MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD).
体内研究：
PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle.
体外研究：
MA-0204 is >10,000-fold selective for activation of PPARδ over PPARα and PPARγ receptors. MA-0204 exhibits high protein binding to mouse plasma, good permeability and low potential for efflux. C.MA-0204 (1.2-12 nM) improves fatty acid oxidation in DMD patient muscle myoblasts mice.MA-0204 (0.04-40 nM) engages target gene expression in DMD patient muscle myoblasts.
MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD).
体内研究：
PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle.
体外研究：
MA-0204 is >10,000-fold selective for activation of PPARδ over PPARα and PPARγ receptors. MA-0204 exhibits high protein binding to mouse plasma, good permeability and low potential for efflux. C.MA-0204 (1.2-12 nM) improves fatty acid oxidation in DMD patient muscle myoblasts mice.MA-0204 (0.04-40 nM) engages target gene expression in DMD patient muscle myoblasts.
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