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编 号:F259010
分子式:C18H17FN2S
分子量:312.4
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生物活性:
CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM.

体内研究:
CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats.

体外研究:
CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 μM against CYP3A4.
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