产品
编 号：F258967
分子式：C24H17ClF2N2O2
分子量：438.85
分子式：C24H17ClF2N2O2
分子量：438.85
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2092923-21-0
产品详情
生物活性：
VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration.
体内研究：
VU 6008667(1 mg/kg或者3mg/kg，口服作用于大鼠）较小的体积（Vss = 7.4 L/kg）和较高的清除率，显示半衰期为2.3小时（t1/2 = 2.3 hr),CLp = 82 mL/min/kg，显示口服生物利用度为17%(17％F)。Animal Model:RAT (PK study)
Dosage:1 mg/kg; 3 mg/kg
Administration:oral adminstration
Result:Had a desired short half-life in rat (t1/2= 2.3 hr), with moderate oral bioavailability (17% F).
VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration.
体内研究：
VU 6008667(1 mg/kg或者3mg/kg，口服作用于大鼠）较小的体积（Vss = 7.4 L/kg）和较高的清除率，显示半衰期为2.3小时（t1/2 = 2.3 hr),CLp = 82 mL/min/kg，显示口服生物利用度为17%(17％F)。Animal Model:RAT (PK study)
Dosage:1 mg/kg; 3 mg/kg
Administration:oral adminstration
Result:Had a desired short half-life in rat (t1/2= 2.3 hr), with moderate oral bioavailability (17% F).
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