产品
编 号：F255748
分子式：C23H27NO4
分子量：381.46
分子式：C23H27NO4
分子量：381.46
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 2089415-51-8
产品详情
生物活性：
PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget agent candidate against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD agent development.
体内研究：
PQM130 (0.5-1 mg/kg, i.p., daily for 10 days) treatment after the i.c.v. AβO injection reduces oxidative damage and neuroinflammation and induces cell survival and protein synthesis through the modulation of GSK3β and extracellular signal-regulated kinases (ERK1/2) .Animal Model:Adult male C57Bl/6 mice (9 weeks old, 25-30 g body weight) .
Dosage:0.5 and 1.0 mg/kg.
Administration:IP injection daily for 10 days.
Result:Ameliorated Aβ1-42O-induced cognitive deficits in mice.Prevented Aβ1-42O-induced neuronal death in mice.Antagonized Aβ1-42O-Induced Oxidative Stress in Mice.Regulated GSK3β and ERK1/2 protein expressions in mice.Reduced Aβ1-42O-induced astrocytic activation in mice.
PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget agent candidate against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD agent development.
体内研究：
PQM130 (0.5-1 mg/kg, i.p., daily for 10 days) treatment after the i.c.v. AβO injection reduces oxidative damage and neuroinflammation and induces cell survival and protein synthesis through the modulation of GSK3β and extracellular signal-regulated kinases (ERK1/2) .Animal Model:Adult male C57Bl/6 mice (9 weeks old, 25-30 g body weight) .
Dosage:0.5 and 1.0 mg/kg.
Administration:IP injection daily for 10 days.
Result:Ameliorated Aβ1-42O-induced cognitive deficits in mice.Prevented Aβ1-42O-induced neuronal death in mice.Antagonized Aβ1-42O-Induced Oxidative Stress in Mice.Regulated GSK3β and ERK1/2 protein expressions in mice.Reduced Aβ1-42O-induced astrocytic activation in mice.
产品资料
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