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编 号：F255414
分子式：C20H18NO4+
分子量：336.36
分子式：C20H18NO4+
分子量：336.36
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CAS No: 2086-83-1
产品详情
生物活性：
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability.
体内研究：
Berberine (10, 30, or 50 mg/kg/day; gastrointestinal gavage; for 10 consecutive days) inhibits the growth of human colorectal adenocarcinoma in vivo. Berberine at doses of 30 and 50 mg/kg/day taken by gastrointestinal gavage shows inhibitory rates of 33.1% and 45.3% on the human colorectal adenocarcinoma xenograft growth in nude mice.Animal Model:5-week-old BALB/c nu/nu mice with human colorectal adenocarcinoma LoVo xenografts
Dosage:10, 30, or 50 mg/kg/day
Administration:Gastrointestinal gavage; for 10 consecutive days
Result:Showed inhibitory rates of 33.1 % and 45.3 % at doses of 30 and 50 mg/kg/day.
体外研究：
Berberine suLfate (1.25-160 μM；72 hours) 对四种结直肠癌细胞系 LoVo、HCT116、SW480 和 HT-29 的增殖具有潜在的抑制作用。Berberine suLfate (1.25-160 μM；24-72 小时) 诱导 LoVo 细胞生长的时间和剂量依赖性抑制。LoVo 细胞暴露于硫酸 Berberine sulfate (10 -80 μM) 24 小时。通过流式细胞仪对 40 μM 小檗碱处理的 LoVo 细胞进行细胞周期分析显示细胞在 G2/M 期积累。硫酸 Berberine sulfate (10 -80 μM) 抑制细胞周期蛋白 B1、cdc2和cdc25c蛋白在24 h后的表达，尤其是在80.0 μM剂量下。Berberine hemisulfate 通过抑制细胞分裂蛋白 (FtsZ) 或通过结合 DNA/RNA 并造成 DNA/RNA 损伤，发挥抗菌活性。Berberine hemisulfate 通过抑制 TNF-α 及其下游通路 AP-1 和 NF-kB 的激活，发挥抗炎活性。 Berberine hemisulfate 通过抑制活性氧 (ROS) 的产生和 caspase 激活，激活 PI3K/Akt 信号通路和上调血红素加氧酶-1 (HO-1) 表达，发挥神经保护活性。Berberine hemisulfate 通过调节脂质和抑制胰岛素抵抗来改善代谢疾病。
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability.
体内研究：
Berberine (10, 30, or 50 mg/kg/day; gastrointestinal gavage; for 10 consecutive days) inhibits the growth of human colorectal adenocarcinoma in vivo. Berberine at doses of 30 and 50 mg/kg/day taken by gastrointestinal gavage shows inhibitory rates of 33.1% and 45.3% on the human colorectal adenocarcinoma xenograft growth in nude mice.Animal Model:5-week-old BALB/c nu/nu mice with human colorectal adenocarcinoma LoVo xenografts
Dosage:10, 30, or 50 mg/kg/day
Administration:Gastrointestinal gavage; for 10 consecutive days
Result:Showed inhibitory rates of 33.1 % and 45.3 % at doses of 30 and 50 mg/kg/day.
体外研究：
Berberine suLfate (1.25-160 μM；72 hours) 对四种结直肠癌细胞系 LoVo、HCT116、SW480 和 HT-29 的增殖具有潜在的抑制作用。Berberine suLfate (1.25-160 μM；24-72 小时) 诱导 LoVo 细胞生长的时间和剂量依赖性抑制。LoVo 细胞暴露于硫酸 Berberine sulfate (10 -80 μM) 24 小时。通过流式细胞仪对 40 μM 小檗碱处理的 LoVo 细胞进行细胞周期分析显示细胞在 G2/M 期积累。硫酸 Berberine sulfate (10 -80 μM) 抑制细胞周期蛋白 B1、cdc2和cdc25c蛋白在24 h后的表达，尤其是在80.0 μM剂量下。Berberine hemisulfate 通过抑制细胞分裂蛋白 (FtsZ) 或通过结合 DNA/RNA 并造成 DNA/RNA 损伤，发挥抗菌活性。Berberine hemisulfate 通过抑制 TNF-α 及其下游通路 AP-1 和 NF-kB 的激活，发挥抗炎活性。 Berberine hemisulfate 通过抑制活性氧 (ROS) 的产生和 caspase 激活，激活 PI3K/Akt 信号通路和上调血红素加氧酶-1 (HO-1) 表达，发挥神经保护活性。Berberine hemisulfate 通过调节脂质和抑制胰岛素抵抗来改善代谢疾病。
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