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编 号：F029352
分子式：C18H19FN8O
分子量：382.39
分子式：C18H19FN8O
分子量：382.39
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CAS No: 1079274-94-4
产品详情
生物活性：
Utatrectinib (AZD-7451) is a potent, selective and orally active Trk inhibitor. Utatrectinib blocks TrkC activation and associated tumorigenic behaviors.
体内研究：
Utatrectinib (50 mg/kg, p.o., daily) suppresses adenoid cystic carcinoma (ACC) tumor growth in ACCX6 xenograft nu/nu mice model.Animal Model:Xenograft nu/nu mice models of human ACC: ACCX6 and ACCX9
Dosage:50 mg/kg
Administration:Oral administration, daily.
Result:Tumor growth inhibition (TGI): 64% (in ACCX6 model)
体外研究：
Utatrectinib (100 nM, 22 h) inhibits the migration of TrkC-expressing U2SO cells.Utatrectinib (1-10 nM, 24 h) inhibits cell growth in KM12, H460 and H810 cells.Utatrectinib (5 nM, 24 h) inhibits phosphorylation of TRKA/B and downstream signaling in KM12, H460 cells.
Utatrectinib (AZD-7451) is a potent, selective and orally active Trk inhibitor. Utatrectinib blocks TrkC activation and associated tumorigenic behaviors.
体内研究：
Utatrectinib (50 mg/kg, p.o., daily) suppresses adenoid cystic carcinoma (ACC) tumor growth in ACCX6 xenograft nu/nu mice model.Animal Model:Xenograft nu/nu mice models of human ACC: ACCX6 and ACCX9
Dosage:50 mg/kg
Administration:Oral administration, daily.
Result:Tumor growth inhibition (TGI): 64% (in ACCX6 model)
体外研究：
Utatrectinib (100 nM, 22 h) inhibits the migration of TrkC-expressing U2SO cells.Utatrectinib (1-10 nM, 24 h) inhibits cell growth in KM12, H460 and H810 cells.Utatrectinib (5 nM, 24 h) inhibits phosphorylation of TRKA/B and downstream signaling in KM12, H460 cells.
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