产品
编 号：F254813
分子式：C19H24NO3.1/2Ca.H2O
分子量：352.46
分子式：C19H24NO3.1/2Ca.H2O
分子量：352.46
产品类型
规格
价格
是否有货
100mg
280
In-stock
500mg
784
In-stock
结构图
CAS No: 207844-01-7
产品详情
生物活性：
Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes.
体内研究：
Mitiglinide Calcium hydrate (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load.Animal Model:Pregnant Wistar rats (12 weeks)
Dosage:0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:Oral administration
Result:Dose-dependently suppressed AUCglucose levels.
体外研究：
Mitiglinide calcium hydrate inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells.
Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes.
体内研究：
Mitiglinide Calcium hydrate (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load.Animal Model:Pregnant Wistar rats (12 weeks)
Dosage:0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:Oral administration
Result:Dose-dependently suppressed AUCglucose levels.
体外研究：
Mitiglinide calcium hydrate inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备