产品
编 号：F254220
分子式：C15H19ClN2
分子量：262.78
分子式：C15H19ClN2
分子量：262.78
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 2070015-10-8
产品详情
生物活性：
ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels.
体内研究：
ML204 hydrochloride (1?mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice.Animal Model:Nonfasted male C57BL/6 (2-3 months)
Dosage:1?mg/kg
Administration:Subcutaneous injection, twice a day, for 5 days (prior to LPS injection)
Result:Induces mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response.
体外研究：
ML204 hydrochloride inhibits TRPC4β-mediated intracellular Ca2+ rise with an IC50 value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation.ML204 hydrochloride blocks TRPC4β activity induced through either Gi/o stimulation by μ-opioid, 5HT1A serotonin, and M2 muscarinic receptors or Gq/11 stimulation by the endogenous M3-like muscarinic receptors.ML204 hydrochloride blocks LPS-induced TRPC5 channel activity.
ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels.
体内研究：
ML204 hydrochloride (1?mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice.Animal Model:Nonfasted male C57BL/6 (2-3 months)
Dosage:1?mg/kg
Administration:Subcutaneous injection, twice a day, for 5 days (prior to LPS injection)
Result:Induces mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response.
体外研究：
ML204 hydrochloride inhibits TRPC4β-mediated intracellular Ca2+ rise with an IC50 value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation.ML204 hydrochloride blocks TRPC4β activity induced through either Gi/o stimulation by μ-opioid, 5HT1A serotonin, and M2 muscarinic receptors or Gq/11 stimulation by the endogenous M3-like muscarinic receptors.ML204 hydrochloride blocks LPS-induced TRPC5 channel activity.
产品资料
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