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编 号：F254175
分子式：C24H40O5.xH2O.Na
分子式：C24H40O5.xH2O.Na
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CAS No: 206986-87-0
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生物活性：
Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic acid sodium hydrate is orally active.
体内研究：
Cholic acid(1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity.Animal Model:Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20–25 g)
Dosage:1% (w/w) Cholic acid-supplemented diet
Administration:Oral, 14 days
Result:Decreases SHP expression and increased CYP2D6 activity.
体外研究：
Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway.
Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic acid sodium hydrate is orally active.
体内研究：
Cholic acid(1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity.Animal Model:Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20–25 g)
Dosage:1% (w/w) Cholic acid-supplemented diet
Administration:Oral, 14 days
Result:Decreases SHP expression and increased CYP2D6 activity.
体外研究：
Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway.
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