产品
编 号：F029167
分子式：C23H20FNO5
分子量：409.41
分子式：C23H20FNO5
分子量：409.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1078166-57-0
产品详情
生物活性：
PF-04418948 is an orally active, potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM.
体内研究：
PF-04418948 (oral gavage; 1, 3, and 10 mg/kg; once) attenuats the butaprost-induced cutaneous blood flow response.Animal Model:Sprague Dawley rats
Dosage:1, 3, and 10 mg/kg
Administration:Oral gavage; 1, 3, and 10 mg/kg; once
Result:Reduced the peak and AUC butaprost-induced cutaneous blood flow response in a dose-dependent fashion.
体外研究：
PF-04418948 (2 μM; 90 min) inhibits prostaglandin E2 (PGE2)-induced increase in cAMP.
PF-04418948 is an orally active, potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM.
体内研究：
PF-04418948 (oral gavage; 1, 3, and 10 mg/kg; once) attenuats the butaprost-induced cutaneous blood flow response.Animal Model:Sprague Dawley rats
Dosage:1, 3, and 10 mg/kg
Administration:Oral gavage; 1, 3, and 10 mg/kg; once
Result:Reduced the peak and AUC butaprost-induced cutaneous blood flow response in a dose-dependent fashion.
体外研究：
PF-04418948 (2 μM; 90 min) inhibits prostaglandin E2 (PGE2)-induced increase in cAMP.
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