产品
编 号：F253838
分子式：C22H29N3O4S
分子量：431.55
分子式：C22H29N3O4S
分子量：431.55
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CAS No: 206449-93-6
产品详情
生物活性：
(Z)-Lafutidine ((Z)-FRG-8813) is a potent histamine H2 receptor antagonist. (Z)-Lafutidine shows anti-secretory and gastroprotective activities.
体内研究：
(Z)-Lafutidine (Compound 16)stimulates mucin biosynthesis in rat gastric mucosa and this effect not directly due to histamine H2 receptor antagonism.Animal Model:Eight- to nine-week-old male C57BL/6 mice weighing 20-24g
Dosage:3-30 mg/kg
Administration:P.o; twice for 6 days (5-FU: 50 mg/kg; i.p.;once daily)
Result:Reduced the severity of diarrhea during 5-FU treatment,in a mostly dose-dependent manner, and a significant effect was observed at a dose of 30 mg/kg.
(Z)-Lafutidine ((Z)-FRG-8813) is a potent histamine H2 receptor antagonist. (Z)-Lafutidine shows anti-secretory and gastroprotective activities.
体内研究：
(Z)-Lafutidine (Compound 16)stimulates mucin biosynthesis in rat gastric mucosa and this effect not directly due to histamine H2 receptor antagonism.Animal Model:Eight- to nine-week-old male C57BL/6 mice weighing 20-24g
Dosage:3-30 mg/kg
Administration:P.o; twice for 6 days (5-FU: 50 mg/kg; i.p.;once daily)
Result:Reduced the severity of diarrhea during 5-FU treatment,in a mostly dose-dependent manner, and a significant effect was observed at a dose of 30 mg/kg.
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