产品
编 号:F253516
分子式:C15H18O3
分子量:246.3
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. In addition, PPOH acts on CYP4A2 and CYP4A3 with the IC50 values of 22 μM and 6.5 μM, respectively. PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体外研究:
PPOH (5 μM) 可以分别抑制 CYP2C9 的活性 63% 和 90%,在没有和存在 30 分钟 NADPH 预孵化的情况下,当 30 分钟预孵化省略NADPH 时,可以抑制 63%。
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