产品
编 号：F028981
分子式：C24H30O6
分子量：414.49
分子式：C24H30O6
分子量：414.49
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
357
In-stock
10mg
572
In-stock
50mg
1520
In-stock
100mg
1960
In-stock
结构图
CAS No: 107724-20-9
产品详情
生物活性：
Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV).
体内研究：
Eplerenone (口服，200 mg/kg/天，持续 3 个月) 显著降低动脉粥样硬化载脂蛋白缺陷 (EO) 小鼠的氧化应激和动脉粥样硬化进展。Animal Model:Atherosclerotic apolipoprotein Edeficient (EO) mice
Dosage:200 mg/kg
Administration:oral, 200 mg/kg/day for 3 months
Result:Significantly decreased systolic and diastolic blood pressure by 12% and 11%, respectively.Decreased serum susceptibility to lipid peroxidation by as much as 26%, and increased serum paraoxonase activity by 28%.Reduced levels of lipid peroxides, and significantly reduced macrophage oxidation of low-density lipoprotein (LDL) and superoxide ion release.Significantly reduced the atherosclerotic lesion area.
体外研究：
Eplerenone 抑制人盐皮质激素受体，IC50 值为 0.081 μM。
Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV).
体内研究：
Eplerenone (口服，200 mg/kg/天，持续 3 个月) 显著降低动脉粥样硬化载脂蛋白缺陷 (EO) 小鼠的氧化应激和动脉粥样硬化进展。Animal Model:Atherosclerotic apolipoprotein Edeficient (EO) mice
Dosage:200 mg/kg
Administration:oral, 200 mg/kg/day for 3 months
Result:Significantly decreased systolic and diastolic blood pressure by 12% and 11%, respectively.Decreased serum susceptibility to lipid peroxidation by as much as 26%, and increased serum paraoxonase activity by 28%.Reduced levels of lipid peroxides, and significantly reduced macrophage oxidation of low-density lipoprotein (LDL) and superoxide ion release.Significantly reduced the atherosclerotic lesion area.
体外研究：
Eplerenone 抑制人盐皮质激素受体，IC50 值为 0.081 μM。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备