产品
编 号：F252252
分子式：C5H15N2O3PS
分子量：214.22
分子式：C5H15N2O3PS
分子量：214.22
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
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询价
10mg
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50mg
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100mg
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200mg
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结构图
CAS No: 20537-88-6
产品详情
生物活性：
Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action.
体内研究：
Amifostine (静脉注射，400 mg/kg，4 小时) 对雄性 C57BL/6 小鼠心肌 I/R 损伤具有保护作用。Animal Model:Male C57BL/6 mice with myocardial I/R injury
Dosage:400 mg/kg
Administration:Intravenous injection; 4 hours
Result:Attenuated cardiomyocyte apoptosis and reduced the production of I/R-induced ROS.Significantly reduced the expression of cleaved caspase 3 and Bax whileenhanced the expression of SOD1, SOD2 and Bcl2.Significantly increased SOD activity and reduced MDA levels.
体外研究：
Amifostine (0.78125-100 μM，24 h) 以剂量依赖性方式减少叔丁基氢过氧化物 (TBHP) 诱导的细胞损伤，并在 100 μM 浓度下显著减少 H9c2 细胞凋亡。
Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action.
体内研究：
Amifostine (静脉注射，400 mg/kg，4 小时) 对雄性 C57BL/6 小鼠心肌 I/R 损伤具有保护作用。Animal Model:Male C57BL/6 mice with myocardial I/R injury
Dosage:400 mg/kg
Administration:Intravenous injection; 4 hours
Result:Attenuated cardiomyocyte apoptosis and reduced the production of I/R-induced ROS.Significantly reduced the expression of cleaved caspase 3 and Bax whileenhanced the expression of SOD1, SOD2 and Bcl2.Significantly increased SOD activity and reduced MDA levels.
体外研究：
Amifostine (0.78125-100 μM，24 h) 以剂量依赖性方式减少叔丁基氢过氧化物 (TBHP) 诱导的细胞损伤，并在 100 μM 浓度下显著减少 H9c2 细胞凋亡。
产品资料
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