产品
编 号：F252210
分子式：C11H13NO5
分子量：239.23
分子式：C11H13NO5
分子量：239.23
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 205309-81-5
产品详情
生物活性：
DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively.
体内研究：
DL-TBOA (10 nmol；icv，大鼠) 显著促进 Naloxone 诱发的躯体症状和条件性位置厌恶的表达。Animal Model:Male Sprague-Dawley rats (180-250 g)
Dosage:1 nmol, 3 nmol, 10 nmol
Administration:Intracerebroventricularly injection (i.c.v.)
Result:Dose dependently facilitated various somatic signs induced by Naloxone (0.1 mg/kg).
体外研究：
DL-TBOA (70-350 μM；48 小时；HCT116 和 LoVo 细胞系) 处理浓度依赖性地增强 SN38 诱导的活力丧失。DL-TBOA 逆转 Oxaliplatin 诱导的活力丧失。 DL-TBOA (350 μM；24 小时；HCT116 和 LoVo 细胞系) 处理减少 SN38 和 Oxaliplatin 对 p53 的诱导。
DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively.
体内研究：
DL-TBOA (10 nmol；icv，大鼠) 显著促进 Naloxone 诱发的躯体症状和条件性位置厌恶的表达。Animal Model:Male Sprague-Dawley rats (180-250 g)
Dosage:1 nmol, 3 nmol, 10 nmol
Administration:Intracerebroventricularly injection (i.c.v.)
Result:Dose dependently facilitated various somatic signs induced by Naloxone (0.1 mg/kg).
体外研究：
DL-TBOA (70-350 μM；48 小时；HCT116 和 LoVo 细胞系) 处理浓度依赖性地增强 SN38 诱导的活力丧失。DL-TBOA 逆转 Oxaliplatin 诱导的活力丧失。 DL-TBOA (350 μM；24 小时；HCT116 和 LoVo 细胞系) 处理减少 SN38 和 Oxaliplatin 对 p53 的诱导。
产品资料
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