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编 号：F252173
分子式：C20H30N2O7S
分子量：442.53
分子式：C20H30N2O7S
分子量：442.53
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CAS No: 205242-62-2
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生物活性：
NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions.
体内研究：
NAS-181 (20 mg/kg; s.c.) increases the 5-HTP accumulation in rat brain regions.Animal Model:Rats
Dosage:20 mg/kg
Administration:S.c.
Result:Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal?cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40?60%).
体外研究：
NAS-181 (compound (R)-25) (0-1000 nM) increases the K+-stimulated release of [3H]-5-HT from rat occipital cortical slices.NAS-181 (3 mg/kg; s.c.) increases in the number of wet dog shakes in rats, and the effect is abolished by pretreatment of the rats with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pCPA) (200 mg/kg; i.p.).
NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions.
体内研究：
NAS-181 (20 mg/kg; s.c.) increases the 5-HTP accumulation in rat brain regions.Animal Model:Rats
Dosage:20 mg/kg
Administration:S.c.
Result:Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal?cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40?60%).
体外研究：
NAS-181 (compound (R)-25) (0-1000 nM) increases the K+-stimulated release of [3H]-5-HT from rat occipital cortical slices.NAS-181 (3 mg/kg; s.c.) increases in the number of wet dog shakes in rats, and the effect is abolished by pretreatment of the rats with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pCPA) (200 mg/kg; i.p.).
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