产品
编 号：F252055
分子式：C6H10S3
分子量：178.34
分子式：C6H10S3
分子量：178.34
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
25mg
240
In-stock
50mg
400
In-stock
结构图
CAS No: 2050-87-5
产品详情
生物活性：
Diallyl Trisulfide is an orally active anticancer agent that can be isolated from garlic. Diallyl Trisulfide has the ability to induce apoptosis and exhibits anticancer, anti-inflammatory, antioxidant, and antibacterial activities. Diallyl Trisulfide can be used to study a variety of cancers, including liver, colon and prostate cancer.
体内研究：
Diallyl Trisulfide (6 μM/只; 口服，隔天一次持续 30 天) 在 BALB/c 裸鼠中能抑制肿瘤生长，具有抗癌活性。Diallyl Trisulfide (20-80 mg/kg; 口服，单剂量) 在萘 (100 mg/kg; 口服，单剂量) 诱导的昆明小鼠中具有抗氧化和抗炎活性。Diallyl Trisulfide (30 mg/kg; 腹腔注射; 一天一次连续 2 周) 在 BABL/c 小鼠中减少 H9N2 AIV 感染引起的小鼠的肺水肿和炎症，具有抗病毒活性。Animal Model:Kunming mouse model of inflammation induced by naphthalene
Dosage:20 mg/kg, 40 mg/kg, 80 mg/kg
Administration:Oral gavage (p.o.); Single dose. Before naphthalene treatment (100 mg/kg; p.o., single dose)
Result:Inhibited the production of serum nitric oxide (NO) and pulmonary myeloperoxidase (MPO).Significantly reduced the area of inflammatory cell infiltration induced by naphthalene and alleviated lung injury in mice.
Animal Model:BABL/c mice model infected with H9N2 AIV
Dosage:30 mg/kg
Administration:Intraperitoneal injection (i.p.); Once daily for two weeks
Result:Reduced the severity of pulmonary edema.Significantly reduced viral load in mouse lungs.
体外研究：
Diallyl Trisulfide (25-100 μM; 24-72 h) 在 A549 细胞中诱导细胞凋亡，抑制细胞增殖，具有抗癌活性。Diallyl Trisulfide (5-10 μM; 1 h) 通过提高超氧化物歧化酶 (SOD) 活性，显著抑制萘 (20 μM) 刺激的 ROS 生成以及降低炎症因子 IL-6、TNF-α、IL-8 的水平，从而具有抗氧化和抗炎活性。Diallyl Trisulfide (93.75-375 μM; 24 h) 在人肺 A549 上皮细胞中减轻 H9N2 禽流感病毒 (AIV) 引起的感染，具有抗病毒活性。Diallyl Trisulfide 抑制扩张性青霉 (最低杀真菌浓度 (MFC)99值: ≤ 90 μg/mL) 的生长，具有抗真菌活性。
Diallyl Trisulfide is an orally active anticancer agent that can be isolated from garlic. Diallyl Trisulfide has the ability to induce apoptosis and exhibits anticancer, anti-inflammatory, antioxidant, and antibacterial activities. Diallyl Trisulfide can be used to study a variety of cancers, including liver, colon and prostate cancer.
体内研究：
Diallyl Trisulfide (6 μM/只; 口服，隔天一次持续 30 天) 在 BALB/c 裸鼠中能抑制肿瘤生长，具有抗癌活性。Diallyl Trisulfide (20-80 mg/kg; 口服，单剂量) 在萘 (100 mg/kg; 口服，单剂量) 诱导的昆明小鼠中具有抗氧化和抗炎活性。Diallyl Trisulfide (30 mg/kg; 腹腔注射; 一天一次连续 2 周) 在 BABL/c 小鼠中减少 H9N2 AIV 感染引起的小鼠的肺水肿和炎症，具有抗病毒活性。Animal Model:Kunming mouse model of inflammation induced by naphthalene
Dosage:20 mg/kg, 40 mg/kg, 80 mg/kg
Administration:Oral gavage (p.o.); Single dose. Before naphthalene treatment (100 mg/kg; p.o., single dose)
Result:Inhibited the production of serum nitric oxide (NO) and pulmonary myeloperoxidase (MPO).Significantly reduced the area of inflammatory cell infiltration induced by naphthalene and alleviated lung injury in mice.
Animal Model:BABL/c mice model infected with H9N2 AIV
Dosage:30 mg/kg
Administration:Intraperitoneal injection (i.p.); Once daily for two weeks
Result:Reduced the severity of pulmonary edema.Significantly reduced viral load in mouse lungs.
体外研究：
Diallyl Trisulfide (25-100 μM; 24-72 h) 在 A549 细胞中诱导细胞凋亡，抑制细胞增殖，具有抗癌活性。Diallyl Trisulfide (5-10 μM; 1 h) 通过提高超氧化物歧化酶 (SOD) 活性，显著抑制萘 (20 μM) 刺激的 ROS 生成以及降低炎症因子 IL-6、TNF-α、IL-8 的水平，从而具有抗氧化和抗炎活性。Diallyl Trisulfide (93.75-375 μM; 24 h) 在人肺 A549 上皮细胞中减轻 H9N2 禽流感病毒 (AIV) 引起的感染，具有抗病毒活性。Diallyl Trisulfide 抑制扩张性青霉 (最低杀真菌浓度 (MFC)99值: ≤ 90 μg/mL) 的生长，具有抗真菌活性。
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