产品
编 号：F028875
分子式：C9H6O3
分子量：162.14
分子式：C9H6O3
分子量：162.14
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
400
In-stock
结构图
CAS No: 1076-38-6
产品详情
生物活性：
4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects.
体内研究：
4-Hydroxycoumarin (10, 20 或 40 mg/kg/天, 灌胃) 在黑色素瘤小鼠中能有效地抑制肿瘤生长，提高生存率。4-Hydroxycoumarin (5, 10, 25, 50 mg/kg/天, 口服) 在三硝基苯磺酸引起的大鼠结肠炎模型中能显著减轻症状。Animal Model:Mouse melanoma model
Dosage:10, 20 or 40 mg/kg
Administration:i.g.
Result: Reduced >85% of the number of pulmonary tumors.Diminished the tumor size from day 22 and increased survival time at 10 mg/kg/day.
Animal Model:Rat colitis model
Dosage:5, 10, 25, 50 mg/kg
Administration:p.o.
Result:Reduced damage score and extension of the lesion at doses of 10 and 25 mg/kg.Counteracted GSH content and reduced AP activity at a dose of 5 mg/kg.Showed a good recovery of the intestinal cytoarchitecture at doses of 5 and 25 mg/kg.
体外研究：
4-Hydroxycoumarin (0, 50, 160, 500 μM, 24 h) 在 B16-F10 黑色素瘤细胞中破坏肌动蛋白细胞骨架，在 B82 成纤维细胞中没有破坏，但可以降低它们对细胞外基质蛋白的粘附和运动。
4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects.
体内研究：
4-Hydroxycoumarin (10, 20 或 40 mg/kg/天, 灌胃) 在黑色素瘤小鼠中能有效地抑制肿瘤生长，提高生存率。4-Hydroxycoumarin (5, 10, 25, 50 mg/kg/天, 口服) 在三硝基苯磺酸引起的大鼠结肠炎模型中能显著减轻症状。Animal Model:Mouse melanoma model
Dosage:10, 20 or 40 mg/kg
Administration:i.g.
Result: Reduced >85% of the number of pulmonary tumors.Diminished the tumor size from day 22 and increased survival time at 10 mg/kg/day.
Animal Model:Rat colitis model
Dosage:5, 10, 25, 50 mg/kg
Administration:p.o.
Result:Reduced damage score and extension of the lesion at doses of 10 and 25 mg/kg.Counteracted GSH content and reduced AP activity at a dose of 5 mg/kg.Showed a good recovery of the intestinal cytoarchitecture at doses of 5 and 25 mg/kg.
体外研究：
4-Hydroxycoumarin (0, 50, 160, 500 μM, 24 h) 在 B16-F10 黑色素瘤细胞中破坏肌动蛋白细胞骨架，在 B82 成纤维细胞中没有破坏，但可以降低它们对细胞外基质蛋白的粘附和运动。
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