产品
编 号：F250263
分子式：C23H17F3N4O2S2
分子量：502.53
分子式：C23H17F3N4O2S2
分子量：502.53
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CAS No: 2031177-48-5
产品详情
生物活性：
ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active.
体外研究：
ZM223 (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells with IC50s of 100 and 122 nM, respectively.ZM223 (0.1-1 μM; 4 hours) causes a dose-response decrease in the level of NEDD8 and accumulation of the UBC12 protein, indicating the decrease of the subsequent NEDD8-UBC12 complex.
ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active.
体外研究：
ZM223 (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells with IC50s of 100 and 122 nM, respectively.ZM223 (0.1-1 μM; 4 hours) causes a dose-response decrease in the level of NEDD8 and accumulation of the UBC12 protein, indicating the decrease of the subsequent NEDD8-UBC12 complex.
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